Enantiocontrol over Acyclic Quaternary Stereocenters by Acylative Organocatalyzed Kinetic Resolution
نویسندگان
چکیده
In the present paper, we described efficient enantioselective kinetic resolution (KR) of racemic diastereocontrolled secondary alcohols bearing a quaternary stereocenter using commercially available chiral isothiourea organocatalyst. This methodology is general KR leading to enantiocontrol acyclic with high levels stereoselectivity (s up 185) on large scope. The hydroxyl function can easily serve as traceless group by oxidation or reduction process.
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2022
ISSN: ['1434-193X', '1099-0690']
DOI: https://doi.org/10.1002/ejoc.202101475